Malaria vaccines are therapeutics that offer protection against mosquito-borne infectious disease called malaria

 

Malaria Vaccines
Malaria Vaccines

A vaccine for the prevention of malaria is known as a malaria vaccine. RTS,S, also known as Mosquirix, is the only malaria vaccine that has received official approval. By April 2022, 1 million kids who live in places where malaria transmission is moderate to high had received the vaccine. At least three doses are needed in infants by the age of 2, and a fourth dose prolongs the duration of protection for an additional one to two years. Hospital admissions for severe malaria are reduced by the vaccine by about 30%.

Malaria vaccines are therapeutics that provide defence against the infectious disease called malaria that is spread by mosquitoes. A parasite that frequently infects a particular species of mosquito that feeds on humans can result in the serious and occasionally fatal disease known as malaria. Malaria typically causes severe illness in its victims, including high fevers, shivering chills, and flu-like symptoms. Malaria can be fatal, but most cases of illness and death from malaria can be avoided.

With funding from the Bill and Melinda Gates Foundation, the PATH Malaria Vaccines Initiative (MVI) and GlaxoSmithKline (GSK) developed RTS,S. It is a recombinant vaccine made up of pre-erythrocytic P. falciparum circumsporozoite protein (CSP). In addition to producing antibodies that can stop hepatocyte invasion, the CSP antigen triggers a cellular response that allows the hepatocytes to be infected to be destroyed. Due to the CSP vaccine's poor immunogenicity, issues were encountered during the trial stage. By combining the protein with a hepatitis B surface antigen to produce a more potent and immunogenic vaccine, RTS,S attempted to avoid these problems.

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