What is Propylene oxide? What are the uses of it?

 

Propylene Oxide Market
Propylene Oxide Market

Polyethers (the major component of polyurethane foams) and propylene glycol are both made with propylene oxide. Propylene oxide has caused eye and respiratory tract irritation in humans and animals after acute (short-term) exposure. Even with weak concentrations, dermal contact has produced skin irritation and necrosis in people. In humans, propylene oxide is a mild central nervous system (CNS) depressant. In animals chronically (long-term) exposed to propylene oxide by inhalation, inflammatory lesions of the nasal cavity, trachea, and lungs, as well as neurological consequences, have been seen. In mice, propylene oxide has been shown to generate tumours at or around the site of administration, with forestomach tumours following gavage (experimentally placing the chemical in the stomach) and nasal tumours following inhaling exposure. Propylene oxide is designated as a Group B2 probable human carcinogen by the EPA.

According to Coherent Market Insights the Propylene Oxide Market Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2018-2026.

Uses

Propylene oxide is primarily used to make polyethers (the main component of polyurethane foams) and propylene glycol.

Propylene oxide is also employed in the production of dipropylene glycol and glycol ethers, herbicides, solvents, and lubricants, surfactants, and oil demulsifiers, as well as in the fumigation of foods and plastic medical items.

 

Sources and Potential Exposure

Occupational exposure to propylene oxide via inhalation and cutaneous routes may be significant in the production, storage, transportation, and use of the chemical. Occupational exposures, on the other hand, are generally thought to be less than 1 part per million (ppm).

Propylene oxide is projected to be released into the atmosphere largely during its manufacturing or use as an intermediate, as well as as a fumigant and soil sterilant. Inhaling contaminated air in these regions could be a major source of exposure. At a distance of more than 20 km from manufacturing facilities, however, average air concentrations are expected to be less than 10 ppm.

Food products that have been fumigated have been shown to contain propylene oxide; consuming contaminated food is another possible route of exposure.

 

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