Cathepsin Inhibitors; Can Be Used to Treat Cancer, Ebola Infection, and Brain Injuries

Cathepsins are proteases found in all animals as well as other organisms. They are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune responses among a host of other functions. There are distinctive variants of cathepsin inhibitors with each variation advertising different benefits and usefulness against various diseases, such as cancer, Ebola, brain injuries, and others. Thus, there is an increasing demand for cathepsin inhibitors worldwide.

According to the "Coherent Market Insights" Global Industry Insights, Trends, Outlook, and Opportunity Analysis of Cathepsin Inhibitors Market.


Cathepsin Inhibitors Market
Cathepsin Inhibitors Market


There is an increasing demand for novel cancer treatment approaches across the globe, owing to the increasing prevalence of cancer. For instance, according to the American Cancer Society, in 2021, there will be an estimated 1.9 million new cancer cases diagnosed and 608,570 cancer deaths in the United States. Cathepsin D has been found to reduce the immune system's anti-tumor response, and cathepsins B/L are heavily involved in cell invasion. Cathepsin inhibitors stops cell invasion and subsequent metastasis, thereby reducing the risk of cancer spread.

Although there are no approved cathepsin inhibitors in the market, research and development activities are under process for the development of novel cathepsin inhibitors to treat various health conditions. Moreover, cathepsin inhibitors (cathepsin L) were found to prevent severe acute respiratory syndrome coronavirus (SARS) entry. Moreover, a cell-free membrane-fusion system showed that cathepsin L is sufficient to activate membrane fusion by SARS-CoV S.

One class of protein targets that have shown promising results are proteolytic enzymes that involve multiple host proteases involved in viral entry, replication, and effects on the immune system causing the life-threatening symptoms of COVID-19. Furthermore, several members of the cathepsin family of cysteine proteases, including furin, cathepsin L, and the serine proteases factor Xa, tryptase, elastase, plasmin, TMPRSS4, and TMPRSS2, among others. Inhibition of the Cathepsin L and Furin protease might therefore be an efficient way to attenuate the infection process and reduce the spread and severity of COVID-19.

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